MRC & RCOphth John Lee Fellowship

The research to be undertaken will investigate the possibility of developing a molecular treatment to promote regeneration of nerves in the visual system following damage to the optic nerve. Several conditions may cause optic nerve damage, including traumatic optic neuropathy, glaucoma and ischaemic injury, and these can cause severe visual impairment. Once optic nerve damage has occurred, the neurons die and there are currently no effective treatments available to reverse the process and restore vision.  Through manipulation of cellular signalling pathways, we aim to develop a molecule to allow survival of optic nerve cells following injury, and promote regeneration of neurons in order to restore visual function. If successful, this may be translated into new therapies and offer hope for patients who have lost vision from optic nerve conditions.